The vector was a gift from Cindy Miranti (Addgene plasmid # 85973). effects on normal stem cells were, unlike mutations, reversible. Treatment with TET inhibitor suppressed the clonal development of mutant cells in murine models and mutant neoplasia. in myelodysplastic syndromes (MDS) increase with age, with >70% of MDS individuals 80 years or older having … Continue reading The vector was a gift from Cindy Miranti (Addgene plasmid # 85973)